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Article

Disrupted Amino- and Carboxyl-Terminal Interactions of the Androgen Receptor Are Linked to Androgen Insensitivity

1 Jun 2001

Abstract excerpt

We have compared the functional consequences of seven single-point mutations in the ligand-binding domain (LBD) of the androgen receptor (AR). The mutations span helices 3 to 11 and are present in patients suffering from androgen insensitivity syndromes (AIS) and other male-specific disorders. The mutants, except M742V, bound to androgen response elements in vivo and in vitro and showed a testosterone-dependent...

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Identifiers

PMID: 11376111
DOI: 10.1210/mend.15.6.0647

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Source receipt: pubmed, retrieved 7 Sept 2026.

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