Article
Analysis of the transactivation domain of the androgen receptor in patients with male infertility.
Clinical genetics - 1 Sept 1998
Wang Q, Ghadessy F J, Yong E L
Abstract excerpt
Genetic defects of the human androgen receptor (AR) can cause a wide spectrum of androgen insensitivity syndromes (AIS) in XY individuals ranging from phenotypic females, to defective spermatogenesis in otherwise normal males. We screened the non-polymorphic regions of exon 1, transactivation dom...
Topics
- Adult
- Androgens
- Animals
- COS Cells
- Case-Control Studies
- Codon
- DNA Mutational Analysis
- Exons
- Genetic Testing
- Humans
- Immunoblotting
- Infertility, Male
- Male
- Mutation
- Oligospermia
- Polymorphism, Genetic
- Polymorphism, Single-Stranded Conformational
- Receptors, Androgen