Article
Azoospermia associated with a mutation in the ligand-binding domain of an androgen receptor displaying normal ligand binding, but defective trans-activation.
The Journal of clinical endocrinology and metabolism - 1 Dec 1998
Wang Q, Ghadessy F J, Trounson A, de Kretser D, McLachlan R, Ng S C, Yong E L
Abstract excerpt
Although male infertility affects a significant proportion of couples trying to conceive, the cause of defective spermatogenesis is not known in a large number of cases. Ligand binding studies indicate that a number of these subjects may have defects of the androgen receptor (AR). Genetic screeni...
Topics
- Adult
- Alleles
- Amino Acid Substitution
- Androgens
- Cell Line
- Germ-Line Mutation
- Humans
- Ligands
- Male
- Oligospermia
- Receptors, Androgen
- Transcriptional Activation