Article
Molecular basis of androgen receptor diseases.
Annals of medicine - 1 Feb 2000
Yong E L, Lim J, Qi W, Ong V, Mifsud A
Abstract excerpt
androgens act through a single intracellular androgen receptor (AR) which is encoded by a single-copy gene in the X chromosome. Disruption of the AR by genetic mutation results in complete androgen insensitivity syndrome (CAIS) and the female phenotype in otherwise healthy 46XY individuals. Although CAIS is the best known phenotype, recent studies from our laboratory and elsewhere show that malfunction of the AR...
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