Article
Human androgen receptor mutation disrupts ternary interactions between ligand, receptor domains, and the coactivator TIF2 (transcription intermediary factor 2).
Molecular endocrinology (Baltimore, Md.) - 1 Aug 2000
Lim J, Ghadessy F J, Abdullah A A, Pinsky L, Trifiro M, Yong E L
Abstract excerpt
The androgen receptor (AR) is a ligand-dependent X-linked nuclear transcription factor regulating male sexual development and spermatogenesis. The receptor is activated when androgen binds to the C-terminal ligand-binding domain (LBD), triggering a cascade of molecular events, including interactions between the LBD and the N-terminal transactivation domain (TAD), and the recruitment of transcriptional...
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