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Article

CREB controls hepatic lipid metabolism through nuclear hormone receptor PPAR-gamma.

Nature - 13 Nov 2003

Herzig Stephan, Hedrick Susan, Morantte Ianessa, Koo Seung-Hoi, Galimi Francesco, Montminy Marc

Abstract excerpt

Fasting triggers a series of hormonal cues that promote energy balance by inducing glucose output and lipid breakdown in the liver. In response to pancreatic glucagon and adrenal cortisol, the cAMP-responsive transcription factor CREB activates gluconeogenic and fatty acid oxidation programmes by stimulating expression of the nuclear hormone receptor coactivator PGC-1 (refs 2-5). In parallel, fasting also...

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Source

Identifiers

PMID: 14614508
DOI: 10.1038/nature02110

Genes

PGC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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CREB controls hepatic lipid metabolism through nuclear hormone receptor PPAR-gamma.PMID 14614508Read ↗

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The glucocorticoid receptor controls hepatic dyslipidemia through Hes1.Semantic proximity Read ↗

Integrative genomic analysis of CREB defines a critical role for transcription factor networks in mediating the fed/fasted switch in liverSemantic proximity Read ↗

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PGC-1 coactivators in the control of energy metabolismSemantic proximity Read ↗

PGC-1 coactivators: inducible regulators of energy metabolism in health and diseaseSemantic proximity Read ↗

Peroxisome Proliferator-Activated Receptor Coactivator 1 in Caloric Restriction and Other Models of LongevitySemantic proximity Read ↗

Regulation of Hepatic Gluconeogenesis by an ER-Bound Transcription Factor, CREBHSemantic proximity Read ↗

Transcriptome-wide analysis of PGC-1α–binding RNAs identifies genes linked to glucagon metabolic actionSemantic proximity Read ↗

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