Article
Intermolecular disintegration and intramolecular strand transfer activities of wild-type and mutant HIV-1 integrase.
Nucleic acids research - 25 Mar 1994
Mazumder A, Engelman A, Craigie R, Fesen M, Pommier Y
Abstract excerpt
We report the activities of HIV integrase protein on a novel DNA substrate, consisting of a pair of gapped duplex molecules. Integrase catalyzed an intermolecular disintegration reaction that requires positioning of a pair of the gapped duplexes in a configuration that resembles the intgration in...
Topics
- Base Sequence
- DNA
- DNA Nucleotidyltransferases
- DNA, Viral
- Gene Deletion
- HIV-1
- Integrases
- Molecular Sequence Data
- Mutation
- Nucleic Acid Conformation
- Structure-Activity Relationship
- Substrate Specificity