Article
Transgenic mice expressing a human apolipoprotein[a] allele.
Journal of lipid research - 1 Jun 1999
Acquati F, Hammer R, Ercoli B, Mooser V, Tao R, Rönicke V, Michalich A, Chiesa G, Taramelli R, Hobbs H H, Müller H J
Abstract excerpt
The most important determinant of plasma levels of Lp[a] are sequence differences at the highly polymorphic apolipoprotein[a] (apo[a]) locus. To define the sequences that mediate the regulation of apo[a] expression, we cloned a 370 kb DNA fragment that included a 130 kb apo[a] gene, and 40 kb 5'- and 200 kb 3'-flanking region from an individual with high plasma levels of Lp[a] using a YAC vector. This genomic...
Topics
- Alleles
- Animals
- Apolipoproteins A
- Castration
- Chromosomes, Artificial, Yeast
- Dietary Fats
- Estrus
- Female
- Gene Expression Regulation
- Genetic Vectors
- Gonadal Steroid Hormones