Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The Role of High-Mobility Group I(Y) Proteins in Expression of IL-2 and T Cell Proliferation

1 Mar 2000

Abstract excerpt

The high-mobility group I(Y) (HMGI(Y)) family of proteins plays an important architectural role in chromatin and have been implicated in the control of inducible gene expression. We have previously shown that expression of HMGI antisense RNA in Jurkat T cells inhibits the activity of the IL-2 promoter. Here we have investigated the role of HMGI(Y) in controlling IL-2 promoter-reporter constructs as well as the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cytokine Signaling Pathways and Interactions
Share to NF-κB Signaling Pathways
Share to Signaling Pathways in Disease

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 10706706
DOI: 10.4049/jimmunol.164.6.3157

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The Role of High-Mobility Group I(Y) Proteins in Expression of IL-2 and T Cell ProliferationPMID 10706706Read ↗

A role for the architectural transcription factors HMGI(Y) in cytokine gene transcription in T cells.Semantic proximity Read ↗

HMGI(Y) and HMGI-C DysregulationSemantic proximity Read ↗

HMG-I/Y , a New c-Myc Target Gene and Potential OncogeneSemantic proximity Read ↗

Molecular dissection of the architectural transcription factor HMGA2.Semantic proximity Read ↗

Specific binding of high-mobility-group I (HMGI) protein and histone H1 to the upstream AT-rich region of the murine beta interferon promoter: HMGI protein acts as a potential antirepressor of the promoter.Semantic proximity Read ↗

The role of HMG I(Y) in the assembly and function of the IFN-beta enhanceosome.Semantic proximity Read ↗

HMG chromosomal proteins in development and disease.Semantic proximity Read ↗

The <b> <i>HMG-I</i> </b> Oncogene Causes Highly Penetrant, Aggressive Lymphoid Malignancy in Transgenic Mice and Is Overexpressed in Human LeukemiaSemantic proximity Read ↗

High-Mobility Group A2 Protein Modulates hTERT Transcription To Promote TumorigenesisSemantic proximity Read ↗

NF-kappaB mediated transcriptional activation is enhanced by the architectural factor HMGI-C.Semantic proximity Read ↗

Architectural Transcription Factor HMGI(Y) Promotes Tumor Progression and Mesenchymal Transition of Human Epithelial CellsSemantic proximity Read ↗

Tumor promoter induces high mobility group HMG-Y protein expression in transformation-sensitive but not -resistant cells.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.