Article

Adenovirus protein VII binds the A-box of HMGB1 to repress interferon responses

2023-04-18

Abstract excerpt

<h4>ABSTRACT</h4> Viruses hijack host proteins to promote infection and dampen host defenses. Adenovirus encodes the multifunctional protein VII that serves both to compact viral genomes inside the virion and disrupt host chromatin. Protein VII binds the abundant nuclear protein high mobility group box 1 (HMGB1) and sequesters HMGB1 in chromatin. HMGB1 is an abundant host nuclear protein that can also be released...

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Literature Corpus work: b4ce6471-5fe1-5da7-a41d-6fe05e3f6ac7
DOI: 10.1101/2023.04.17.537247

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