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Article

SV40LT highly mutates and immortalizes two fibroblast strains from patients with Wilms' tumor.

Cell structure and function - 1 Feb 1999

Kano Y, Motoda H, Hiragami F, Matsui K, Little J B, Namba M

Abstract excerpt

In order to analyze in detail the process of immortalization of human cells, SV40LT was introduced into two chromosome 11p- fibroblast strains from Wilms' tumor patients. Both fibroblasts, hereafter referred to as CM1 and CM2, displayed the mutant phenotype in the crisis stage of cellular aging. In comparison to a control fibroblast, the density of the CM1 strain was abnormally high while the crisis period of the...

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Source

Identifiers

PMID: 10355877
DOI: 10.1247/csf.24.35

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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