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Article

"Mitotic drive" of expanded CTG repeats in myotonic dystrophy type 1 (DM1).

Human molecular genetics - 1 Apr 2001

Khajavi M, Tari A M, Patel N B, Tsuji K, Siwak D R, Meistrich M L, Terry N H, Ashizawa T

Abstract excerpt

In myotonic dystrophy type 1 (DM1), an expanded CTG repeat shows repeat size instability in somatic and germ line tissues with a strong bias toward further expansion. To investigate the mechanism of this expansion bias, 29 DM1 and six normal lymphoblastoid cell lines (LBCLs) were single-cell cloned from blood cells of 18 DM1 patients and six normal subjects. In all 29 cell lines, the expanded CTG repeat alleles...

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PMID: 11285251
DOI: 10.1093/hmg/10.8.855

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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"Mitotic drive" of expanded CTG repeats in myotonic dystrophy type 1 (DM1).PMID 11285251Read ↗

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