Enhanced proliferative potential in culture of cells from p53-deficient mice.

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Article

Enhanced proliferative potential in culture of cells from p53-deficient mice.

Oncogene - 1 Dec 1993

Tsukada T, Tomooka Y, Takai S, Ueda Y, Nishikawa S, Yagi T, Tokunaga T, Takeda N, Suda Y, Abe S

Abstract excerpt

Normal somatic cells are endowed with limited doubling potential in culture, and the process of immortalization is an inevitable step in neoplastic transformation of the cells. To examine the roles of p53 in this process, the cells of p53-deficient mice were examined for doubling potential. Fibro...

Topics

Aneuploidy
Animals
Base Sequence
Blotting, Southern
Blotting, Western
Bone Marrow
Bone Marrow Cells
Cell Division
Cells, Cultured
Chimera
Chromosomes
DNA
Epithelial Cells
Epithelium
Female
Fibroblasts
Flow Cytometry
Hematopoietic Cell Growth Factors

Source

Open in PubMed

Identifiers

PMID: 7504233

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7504233-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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