Article
A nude mouse Wilms' tumor line (KCMC-WT-1) derived from an aniridia patient with monoalleleic partial deletion of chromosome 11p.
Cancer - 15 Feb 1996
Nagashima Y, Nishihira H, Miyagi Y, Tanaka Y, Sasaki Y, Nishi T, Imaizumi K, Aoki I, Misugi K
Abstract excerpt
BACKGROUND: A candidate tumor suppressor gene, WT-1, is believed to have an important role in the pathogenesis of Wilms' tumor, especially that occurring in patients with congenital aniridia. METHODS: To obtain a stable tumor line to work with, Wilms' tumor tissue was serially transplanted in athymic nude mice. Biopsied Wilms' tumor tissue, derived from an aniridia patient, was transplanted subcutaneously to an...
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