Article
Somatic mutation in the mammary gland: influence of time and estrus.
Mutation research - 1 Jun 1999
Sun B, Shima N, Heddle J A
Abstract excerpt
A critical factor in the quantitation of mutation induction in vivo is the time interval between treatment and sampling. In order to study mutagenesis in the mammary epithelium, the cell type in which breast cancer arises, we have measured the manifestation time, the minimum time required for the maximum mutant frequency to be achieved, in this tissue. The F1 LacZ transgenic mice (Muta MousexSWR) were treated...
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