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Article

[Importance of genotyping of thiopurine S-methyltransferase in children with acute lymphoblastic leukaemia during maintenance therapy].

Srpski arhiv za celokupno lekarstvo - 1 Jan 2000

Dokmanović Lidija, Janić Dragana, Krstovski Nada, Zukić Branka, Tosić Natasa, Pavlović Sonja

Abstract excerpt

INTRODUCTION: Thiopurine S-methyltransferase (TPMT) is an enzyme that catalyses the inactivation of mercaptopurine (MP) which is widely used in the treatment of acute lymphoblastic leukaemia (ALL) of childhood. Potentially fatal myelotoxicity may develop after standard doses of MP in TPMT deficient patients. OBJECTIVES: To establish if individually tailored doses of MP can reduce myelotoxicity in ALL patients...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 19177822
DOI: 10.2298/sarh0812609d

Genes

TPMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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[Importance of genotyping of thiopurine S-methyltransferase in children with acute lymphoblastic leukaemia during maintenance therapy].PMID 19177822Read ↗

Thiopurine S-methyltransferase (TPMT) polymorphisms in children with acute lymphoblastic leukemia, and the need for reduction or cessation of 6-mercaptopurine doses during maintenance therapy: the Polish multicenter analysis.Semantic proximity Read ↗

Influence of thiopurine methyltransferase gene polymorphism on Egyptian children with acute lymphoblastic leukaemia.Semantic proximity Read ↗

[Significance of TPMT activity and TGNs level detection for individualizing 6-mercaptopurine chemotherapy].Semantic proximity Read ↗

Prevalence of TPMT and ITPA gene polymorphisms and effect on mercaptopurine dosage in Chilean children with acute lymphoblastic leukemia.Semantic proximity Read ↗

Dosage of 6-Mercaptopurine in Relation to Genetic TPMT and ITPA Variants: Toward Individualized Pediatric Acute Lymphoblastic Leukemia Maintenance Treatment.Semantic proximity Read ↗

Genetic polymorphism of thiopurine methyltransferase and its clinical relevance for childhood acute lymphoblastic leukemia.Semantic proximity Read ↗

Understanding thiopurine methyltransferase polymorphisms for the targeted treatment of hematologic malignancies.Semantic proximity Read ↗

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[The effect of the adverse events with thiopurine S-methyltransferase gene mutation on outcome of childhood acute lymphoblastic leukemia].Semantic proximity Read ↗

Thiopurine methyltransferase in acute lymphoblastic leukaemia: biochemical and molecular biological aspects.Semantic proximity Read ↗

Determinants of mercaptopurine toxicity in paediatric acute lymphoblastic leukemia maintenance therapy.Semantic proximity Read ↗

Should TPMT genotype and activity be used to monitor 6-mercaptopurine treatment in children with acute lymphoblastic leukaemia?Semantic proximity Read ↗

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