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Article

Thiopurine methyltransferase (TPMT) genotype and early treatment response to mercaptopurine in childhood acute lymphoblastic leukemia.

JAMA - 23 Mar 2005

Stanulla Martin, Schaeffeler Elke, Flohr Thomas, Cario Gunnar, Schrauder André, Zimmermann Martin, Welte Karl, Ludwig Wolf-Dieter, Bartram Claus R, Zanger Ulrich M, Eichelbaum Michel, Schrappe Martin, Schwab Matthias

Abstract excerpt

CONTEXT: Early response to multiagent chemotherapy, including mercaptopurine, as measured by minimal residual disease is an important prognostic factor for children with acute lymphoblastic leukemia (ALL). Thiopurine methyltransferase (TPMT) is involved in the metabolism of mercaptopurine and subject to genetic polymorphism, with heterozygous individuals having intermediate and homozygous mutant individuals...

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Topics

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Share to Antimetabolites, Antineoplastic
Share to Child, Preschool

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Infant

Share to Mercaptopurine

Share to Methyltransferases

Share to Neoplasm, Residual

Share to Precursor Cell Lymphoblastic Leukemia-Lymphoma

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Source

Identifiers

PMID: 15784872
DOI: 10.1001/jama.293.12.1485

Genes

TPMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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