Article
Toward understanding the molecular pathology of Huntington's disease.
Brain pathology (Zurich, Switzerland) - 1 Jul 1997
Wellington C L, Brinkman R R, O'Kusky J R, Hayden M R
Abstract excerpt
Huntington's Disease (HD) is caused by expansion of a CAG trinucleotide beyond 35 repeats within the coding region of a novel gene. Recently, new insights into the relationship between CAG expansion in the HD gene and pathological mechanisms have emerged. Survival analysis of a large cohort of af...
Topics
- Age of Onset
- Carbon-Oxygen Lyases
- DNA-(Apurinic or Apyrimidinic Site) Lyase
- DNA-Binding Proteins
- Humans
- Huntington Disease
- Nerve Tissue Proteins
- Nuclear Proteins
- Peptides
- Phenotype
- Trinucleotide Repeats