Article
Toward understanding the molecular pathology of Huntington's disease.
Brain pathology (Zurich, Switzerland) - 1 Jul 1997
Wellington C L, Brinkman R R, O'Kusky J R, Hayden M R
Abstract excerpt
Huntington's Disease (HD) is caused by expansion of a CAG trinucleotide beyond 35 repeats within the coding region of a novel gene. Recently, new insights into the relationship between CAG expansion in the HD gene and pathological mechanisms have emerged. Survival analysis of a large cohort of affected and at-risk individuals with CAG sizes between 39 and 50 repeats have yielded probability curves of developing...
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