Optimization of apolipoprotein(a) genotyping with pulsed field gel electrophoresis.

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Article

Optimization of apolipoprotein(a) genotyping with pulsed field gel electrophoresis.

Clinical chemistry - 1 Jun 1999

Griffioen P H, Zwang L, van Schaik R H, Engel H, Lindemans J, Cobbaert C M

Abstract excerpt

BACKGROUND: Increased lipoprotein(a) is a risk factor for atherosclerosis, and its concentration in serum is inversely correlated with the size of the apoliprotein(a) [apo(a)] component. The size of the apo(a) gene is determined mainly by the Kringle IV size polymorphism. We have optimized and characterized pulsed field gel electrophoresis (PFGE) for apo(a) genotyping. METHODS: Established PFGE protocols were...

Topics

Alleles
Apolipoproteins A
Coronary Disease
Electrophoresis, Gel, Pulsed-Field
Genotype
Humans
Kringles
Luminescent Measurements
Polymerase Chain Reaction
Reproducibility of Results
Sensitivity and Specificity

Source

Open in PubMed

Identifiers

PMID: 10351984

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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