Article
Optimization of apolipoprotein(a) genotyping with pulsed field gel electrophoresis.
Clinical chemistry - 1 Jun 1999
Griffioen P H, Zwang L, van Schaik R H, Engel H, Lindemans J, Cobbaert C M
Abstract excerpt
BACKGROUND: Increased lipoprotein(a) is a risk factor for atherosclerosis, and its concentration in serum is inversely correlated with the size of the apoliprotein(a) [apo(a)] component. The size of the apo(a) gene is determined mainly by the Kringle IV size polymorphism. We have optimized and characterized pulsed field gel electrophoresis (PFGE) for apo(a) genotyping. METHODS: Established PFGE protocols were...
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