Article
High-precision genotyping by denaturing capillary electrophoresis.
Genome research - 1 Jan 1998
Wenz H, Robertson J M, Menchen S, Oaks F, Demorest D M, Scheibler D, Rosenblum B B, Wike C, Gilbert D A, Efcavitch J W
Abstract excerpt
Genotyping, as applied to linkage mapping, human identification, or mapping of genetic traits, mandates electrophoretic separation systems that enable a user to identify alleles with high precision to obtain a correct genotype. For 2-bp microsatellites or short tandem repeats (STRs), standard deviations of +/-0.3 nucleotide are required to ensure with 99.7% probability the identity or dissimilarity of tested...
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