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Article

Determination of lipoprotein(a) kringle repeat number from genomic DNA: copy number variation genotyping using qPCR.

Journal of lipid research - 1 Apr 2009

Lanktree Matthew B, Rajakumar Chandheeb, Brunt J Howard, Koschinsky Marlys L, Connelly Philip W, Hegele Robert A

Abstract excerpt

Plasma lipoprotein(a) [Lp(a)] concentration is related to risk of cardiovascular disease. The defining protein component of Lp(a) particles, apolipoprotein(a) [apo(a)], is encoded by the LPA gene. Apo(a) is extremely heterogeneous in size due to a common copy number variation, leading to a variable number of kringle-IV type 2 (KIV2)-like domains. Alleles with fewer KIV2 repeats, encoding smaller apo(a) isoforms,...

Topics

Alleles
Base Sequence
DNA
DNA Primers
Genetic Variation
Genotype
Humans
Kringles
Linkage Disequilibrium
Lipoprotein(a)
Minisatellite Repeats

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polymerase Chain Reaction

Source

Open in PubMed Open full text

Identifiers

PMID: 19060253
DOI: 10.1194/jlr.D800050-JLR200
PMCID: PMC2656671

Genes

LPA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-19060253-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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