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Article

Determination of lipoprotein(a) kringle repeat number from genomic DNA: copy number variation genotyping using qPCR.

Journal of lipid research - 1 Apr 2009

Lanktree Matthew B, Rajakumar Chandheeb, Brunt J Howard, Koschinsky Marlys L, Connelly Philip W, Hegele Robert A

Abstract excerpt

Plasma lipoprotein(a) [Lp(a)] concentration is related to risk of cardiovascular disease. The defining protein component of Lp(a) particles, apolipoprotein(a) [apo(a)], is encoded by the LPA gene. Apo(a) is extremely heterogeneous in size due to a common copy number variation, leading to a variable number of kringle-IV type 2 (KIV2)-like domains. Alleles with fewer KIV2 repeats, encoding smaller apo(a) isoforms,...

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Source

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Identifiers

PMID: 19060253
DOI: 10.1194/jlr.D800050-JLR200
PMCID: PMC2656671

Genes

LPA

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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