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Article

Alpha-1-antitrypsin deficiency in Serbian adults with lung diseases.

Genetic testing and molecular biomarkers - 1 Nov 2012

Topic Aleksandra, Stankovic Marija, Divac-Rankov Aleksandra, Petrovic-Stanojevic Natasa, Mitic-Milikic Marija, Nagorni-Obradovic Ljudmila, Radojkovic Dragica

Abstract excerpt

AIM: Alpha-1-antitrypsin (A1AT) is the main inhibitor of neutrophil elastase, and severe alpha-1-antitrypsin deficiency (A1ATD) is a genetic risk factor for early-onset emphysema. Despite the relatively high prevalence of A1ATD, this condition is frequently underdiagnosed. Our aim was to determine the distribution of the A1ATD phenotypes/alleles in patients with lung diseases as well as in the Serbian population....

Topics

Asthma
Bronchiectasis
Humans
Lung Diseases
Odds Ratio
Phenotype
Prevalence
Pulmonary Disease, Chronic Obstructive
Pulmonary Emphysema
Serbia
alpha 1-Antitrypsin

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

alpha 1-Antitrypsin Deficiency

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Identifiers

PMID: 22971141
DOI: 10.1089/gtmb.2012.0152
PMCID: PMC3483045

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