Article
Protease inhibitor phenotypes and serum alpha-1-antitrypsin levels in patients with COPD: a study from Hong Kong.
Respirology (Carlton, Vic.) - 1 Jun 2004
Kwok Janette S Y, Lawton John W M, Yew Wing Wai, Chau Chi Hung, Lee Joseph, Wong Poon Chuen
Abstract excerpt
OBJECTIVE: Many studies have suggested that an imbalance of protease activation and inhibition might result in COPD with emphysema. Levels of alpha-1-antitrypsin (alpha1-AT), the key protease inhibitor, are genetically determined by alleles that present in many phenotypes/subtypes, some of which are associated with deficiency of the protein. We prospectively evaluated the prevalence of the protease inhibitor (Pi)...
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