The Associations of rs1799724 and rs361525 With the Risk of Ankylosing Spondylitis Are Dependent on HLA-B27 Status in a Chinese Han Population.

doi:10.3389/fimmu.2022.852326

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Article

The Associations of rs1799724 and rs361525 With the Risk of Ankylosing Spondylitis Are Dependent on HLA-B27 Status in a Chinese Han Population.

Frontiers in immunology - 1 Jan 2022

Sheng Nan, Gao Yingying, Li Hui, Wang Wenwen, Geng Linyu, Zhang Bo, Huang Qiang, Wang Xueqin, Sun Lingyun

Abstract excerpt

Objectives: Human leucocyte antigen B27 (HLA-B27) is an important biomarker for ankylosing spondylitis (AS). However, delay in the diagnosis of AS is still common in clinical practice. Several single nucleotide polymorphisms (SNPs) in the coding gene of tumor necrosis factor alpha (TNFα) have been reported to be AS susceptibility loci. Our aim was to explore whether SNPs in TNFα could be used to improve the...

Topics

China
Genetic Predisposition to Disease
HLA-B27 Antigen
Humans
Spondylitis, Ankylosing
Tumor Necrosis Factor-alpha

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Identifiers

PMID: 35450075
DOI: 10.3389/fimmu.2022.852326
PMCID: PMC9016113

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