Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Signalling by the RET receptor tyrosine kinase and its role in the development of the mammalian enteric nervous system.

Development (Cambridge, England) - 1 Jun 1999

Taraviras S, Marcos-Gutierrez C V, Durbec P, Jani H, Grigoriou M, Sukumaran M, Wang L C, Hynes M, Raisman G, Pachnis V

Abstract excerpt

RET is a member of the receptor tyrosine kinase (RTK) superfamily, which can transduce signalling by glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) in cultured cells. In order to determine whether in addition to being sufficient, RET is also necessary for signalling by these growth factors, we studied the response to GDNF and NTN of primary neuronal cultures (peripheral sensory and central...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Ciliary Neurotrophic Factor
Share to Digestive System

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Enteric Nervous System

Share to Glial Cell Line-Derived Neurotrophic Factor

Share to Glial Cell Line-Derived Neurotrophic Factor Receptors

Share to Mesencephalon

Share to Neurons, Afferent

Share to Neurotrophin 3

Source

Identifiers

PMID: 10331988
DOI: 10.1242/dev.126.12.2785

Genes

RET
GDNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Signalling by the RET receptor tyrosine kinase and its role in the development of the mammalian enteric nervous system.PMID 10331988Read ↗

Requirement of signalling by receptor tyrosine kinase RET for the directed migration of enteric nervous system progenitor cells during mammalian embryogenesis.Semantic proximity Read ↗

Multipotential progenitors of the mammalian enteric nervous system capable of colonising aganglionic bowel in organ culture.Semantic proximity Read ↗

Diminished Ret expression compromises neuronal survival in the colon and causes intestinal aganglionosis in miceSemantic proximity Read ↗

Ret deficiency decreases neural crest progenitor proliferation and restricts fate potential during enteric nervous system developmentSemantic proximity Read ↗

<i>Ret</i> loss-of-function decreases neural crest progenitor proliferation and restricts developmental fate potential during enteric nervous system developmentSemantic proximity Read ↗

Ret receptor tyrosine kinase sustains proliferation and tissue maturation in intestinal epitheliaSemantic proximity Read ↗

V. Genes, lineages, and tissue interactions in the development of the enteric nervous systemSemantic proximity Read ↗

RET in human development and oncogenesis.Semantic proximity Read ↗

Common origin and developmental dependence on c-ret of subsets of enteric and sympathetic neuroblasts.Semantic proximity Read ↗

Defects in the kidney and enteric nervous system of mice lacking the tyrosine kinase receptor Ret.Semantic proximity Read ↗

Neurotrophic factor receptor RET: structure, cell biology, and inherited diseases.Semantic proximity Read ↗

Lineage-specific intersection of endothelin and GDNF signaling in enteric nervous system developmentSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.