Article

Lineage-specific intersection of endothelin and GDNF signaling in enteric nervous system development

2024-02-14

Abstract excerpt

Two major ligand-receptor signaling axes – endothelin Edn3 and its receptor Ednrb, and glial-derived neurotrophic factor (GDNF) and its receptor Ret – are required for migration of enteric nervous system (ENS) progenitors to the hindgut. Mutations in either component cause colonic aganglionosis, also called Hirschsprung disease. Here, we have used Wnt1Cre and Pax2Cre in mice to show that these driver lines label d...

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Literature Corpus work: 6178f7d2-178c-5d20-b96f-021cdb1465af
DOI: 10.1101/2024.02.13.580135

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