Article
Isl1Cre reveals a common Bmp pathway in heart and limb development.
Development (Cambridge, England) - 1 Apr 2006
Yang Lei, Cai Chen-Leng, Lin Lizhu, Qyang Yibing, Chung Christine, Monteiro Rui M, Mummery Christine L, Fishman Glenn I, Cogen Anna, Evans Sylvia
Abstract excerpt
A number of human congenital disorders present with both heart and limb defects, consistent with common genetic pathways. We have recently shown that the LIM homeodomain transcription factor islet 1 (Isl1) marks a subset of cardiac progenitors. Here, we perform lineage studies with an Isl1Cre mouse line to demonstrate that Isl1 also marks a subset of limb progenitors. In both cardiac and limb progenitors, Isl1...
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