Article
Sustained proliferation of PDX-1+ cells derived from human islets.
Diabetes - 1 May 1999
Beattie G M, Itkin-Ansari P, Cirulli V, Leibowitz G, Lopez A D, Bossie S, Mally M I, Levine F, Hayek A
Abstract excerpt
Ex vivo expansion of human beta-cells is an important step toward the development of cell-based insulin delivery systems in type 1 diabetes. Here, we report that human pancreatic endocrine cells can be expanded through 15 cell doublings in vitro for an estimated total 30,000-fold increase in cell number. We believe that the cells resulting from these cultures are of beta-cell origin, since they uniformly express...
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