Article

HES-1 Is Involved in Adaptation of Adult Human β-Cells to Proliferation In Vitro

2008-07-04

Abstract excerpt

OBJECTIVE—In vitro expansion of β-cells from adult human islets could solve the tissue shortage for cell replacement therapy of diabetes. Culture of human islet cells typically results in &lt;16 cell doublings and loss of insulin expression. Using cell lineage tracing, we demonstrated that the expanded cell population included cells derived from β-cells. Understanding the molecular mechanisms involved in β-cel...

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Literature Corpus work: 6ea8a6da-6032-5c72-bc2a-e719159a2562
DOI: 10.2337/db07-1323

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