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In Vitro Proliferation of Cells Derived From Adult Human β-Cells Revealed By Cell-Lineage Tracing

4 Mar 2008

Abstract excerpt

OBJECTIVE: Expansion of insulin-producing beta-cells from adult human islets could alleviate donor shortage for cell-replacement therapy of diabetes. A major obstacle to development of effective expansion protocols is the rapid loss of beta-cell markers in the cultured cells. Here, we report a genetic cell-lineage tracing approach for following the fate of cultured beta-cells. RESEARCH DESIGN AND METHODS: Cells...

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PMID: 18316362
DOI: 10.2337/db07-1283

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