Article
Temporal trends of HLA genotype frequencies of type 1 diabetes patients in Sweden from 1986 to 2005 suggest altered risk.
Acta diabetologica - 1 Dec 2008
Resic-Lindehammer Sabina, Larsson K, Ortqvist E, Carlsson A, Cederwall E, Cilio C M, Ivarsson S-A, Jönsson B A, Larsson H E, Lynch K, Neiderud J, Nilsson A, Sjöblad S, Lernmark A, Aili M, Bååth L E, Carlsson E, Edenwall H, Forsander G, Granstro B W, Gustavsson I, Hanås R, Hellenberg L, Hellgren H, Holmberg E, Hörnell H, Ivarsson Sten-A, Johansson C, Jonsell G, Kockum K, Lindblad B, Lindh A, Ludvigsson J, Myrdal U, Neiderud J, Segnestam K, Sjöblad S, Skogsberg L, Strömberg L, Ståhle U, Thalme B, Tullus K, Tuvemo T, Wallensteen M, Westphal O, Aman J
Abstract excerpt
The aim of this study was to compare the frequency of human leukocyte antigen (HLA) genotypes in 1-18-year-old patients with type 1 diabetes newly diagnosed in 1986-1987 (n = 430), 1996-2000 (n = 342) and in 2003-2005 (n = 171). We tested the hypothesis that the HLA DQ genotype distribution changes over time. Swedish type 1 diabetes patients and controls were typed for HLA using polymerase chain reaction...
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