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Article

Genetic effects on age-dependent onset and islet cell autoantibody markers in type 1 diabetes.

Diabetes - 1 May 2002

Graham Jinko, Hagopian William A, Kockum Ingrid, Li Lou Sheng, Sanjeevi Carani B, Lowe Robert M, Schaefer Jonathan B, Zarghami Marjan, Day Heather L, Landin-Olsson Mona, Palmer Jerry P, Janer-Villanueva Marta, Hood Leroy, Sundkvist Göran, Lernmark Ake, Breslow Norman, Dahlquist Gisela, Blohmé Göran

Abstract excerpt

Age-dependent associations between type 1 diabetes risk genes HLA, INS VNTR, and CTLA-4 and autoantibodies to GAD65 (GADAs), ICA512/IA-2, insulin, and islet cells were determined by logistic regression analysis in 971 incident patients with type 1 diabetes and 702 control subjects aged 0-34 years. GADAs were associated with HLA-DQ2 in young but not in older patients (P = 0.009). Autoantibodies to insulin were...

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PMID: 11978629
DOI: 10.2337/diabetes.51.5.1346

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Source receipt: pubmed, retrieved 7 Sept 2026.

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