Article
Detection of aneuploidy in patients with cancer through amplification of long interspersed nucleotide elements (LINEs).
Proceedings of the National Academy of Sciences of the United States of America - 20 Feb 2018
Douville Christopher, Springer Simeon, Kinde Isaac, Cohen Joshua D, Hruban Ralph H, Lennon Anne Marie, Papadopoulos Nickolas, Kinzler Kenneth W, Vogelstein Bert, Karchin Rachel
Abstract excerpt
Aneuploidy is a feature of most cancer cells, and a myriad of approaches have been developed to detect it in clinical samples. We previously described primers that could be used to amplify ∼38,000 unique long interspersed nucleotide elements (LINEs) from throughout the genome. Here we have developed an approach to evaluate the sequencing data obtained from these amplicons. This approach, called Within-Sample...
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