Article
Gene expression of myogenic factors and phenotype-specific markers in electrically stimulated muscle of paraplegics.
Journal of applied physiology (Bethesda, Md. : 1985) - 1 Jul 2005
Vissing Kristian, Andersen Jesper L, Harridge Stephen D R, Sandri Claudia, Hartkopp Andreas, Kjaer Michael, Schjerling Peter
Abstract excerpt
The transcription factors myogenin and MyoD have been suggested to be involved in maintaining slow and fast muscle-fiber phenotypes, respectively, in rodents. Whether this is also the case in human muscle is unknown. To test this, 4 wk of chronic, low-frequency electrical stimulation training of the tibialis anterior muscle of paraplegic subjects were used to evoke a fast-to-slow transformation in muscle...
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