Article
Myogenin, MyoD, and myosin heavy chain isoform expression following hindlimb suspension.
Aviation, space, and environmental medicine - 1 May 1999
Mozdziak P E, Greaser M L, Schultz E
Abstract excerpt
BACKGROUND: Myogenin expression is associated with a slow myofiber phenotype, and MyoD expression is associated with a fast myofiber phenotype. Hindlimb suspension (HS) will induce muscular atrophy, and a transition from a slow to fast myofiber phenotype in the rat soleus. HYPOTHESIS: Hindlimb suspension will induce myofiber atrophy, and a slow to fast myofiber type transition with corresponding changes in...
Topics
- Animals
- Blotting, Northern
- Disease Models, Animal
- Female
- Gene Expression Regulation
- Hindlimb Suspension
- Muscle Fibers, Fast-Twitch
- Muscle Fibers, Slow-Twitch
- Muscle, Skeletal
- Muscular Atrophy
- MyoD Protein
- Myogenin
- Myosin Heavy Chains
- Phenotype
- Rats
- Rats, Inbred Strains
- Reverse Transcriptase Polymerase Chain Reaction
- Space Flight