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Article

Notch signaling enhances survival and alters differentiation of 32D myeloblasts.

Journal of immunology (Baltimore, Md. : 1950) - 15 Oct 2000

Tan-Pertel H T, Walker L, Browning D, Miyamoto A, Weinmaster G, Gasson J C

Abstract excerpt

The Notch transmembrane receptors play important roles in precursor survival and cell fate specification during hematopoiesis. To investigate the function of Notch and the signaling events activated by Notch in myeloid development, we expressed truncated forms of Notch1 or Notch2 proteins that either can or cannot activate the core binding factor 1 (CBF1) in 32D (clone 3) myeloblasts. 32D cells proliferate as...

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Source

Identifiers

PMID: 11035081
DOI: 10.4049/jimmunol.165.8.4428

Genes

HES1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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