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Article

Interaction of axin and Dvl-2 proteins regulates Dvl-2-stimulated TCF-dependent transcription.

The EMBO journal - 17 May 1999

Smalley M J, Sara E, Paterson H, Naylor S, Cook D, Jayatilake H, Fryer L G, Hutchinson L, Fry M J, Dale T C

Abstract excerpt

Axin promotes the phosphorylation of beta-catenin by GSK-3beta, leading to beta-catenin degradation. Wnt signals interfere with beta-catenin turnover, resulting in enhanced transcription of target genes through the increased formation of beta-catenin complexes containing TCF transcription factors. Little is known about how GSK-3beta-mediated beta-catenin turnover is regulated in response to Wnt signals. We have...

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Identifiers

PMID: 10329628
DOI: 10.1093/emboj/18.10.2823
PMCID: PMC1171363

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Interaction of axin and Dvl-2 proteins regulates Dvl-2-stimulated TCF-dependent transcription.PMID 10329628Read ↗

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