[Mutation of p53 gene in the transformed fibroblasts detected by nonradioisotopic single strand conformation polymorphism analysis].

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Article

[Mutation of p53 gene in the transformed fibroblasts detected by nonradioisotopic single strand conformation polymorphism analysis].

Wei sheng yan jiu = Journal of hygiene research - 1 May 1997

Tan M, Wang L E, Xie D, Li Y

Abstract excerpt

The human embryonic lung fibroblasts transformation was induced by chemical mutant Glycidyl Methacrylate (GMA) in vitro. Transformed clonies were isolated and then exon 5 and exon 8 of p53 gene were specifically amplified by polymerase chain reaction. Amplified fragments were detected by using silver stained single strand conformation polymorphism analysis. The results showed that exon 8 altered in the...

Topics

Air Pollutants, Occupational
Cell Transformation, Neoplastic
Embryo, Mammalian
Epoxy Compounds
Fibroblasts
Genes, p53
Humans
Lung
Methacrylates
Mutation
Polymerase Chain Reaction
Polymorphism, Single-Stranded Conformational

Source

Open in PubMed

Identifiers

PMID: 10325625

Provenance

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