Article
[p53 gene mutations in BALB/c 3T3 cells transformed by crocidolite].
Hua xi yi ke da xue xue bao = Journal of West China University of Medical Sciences = Huaxi yike daxue xuebao - 1 Dec 1997
Lin F, Zhai C, Liu Y, Zhou G, Sun Z, Li S
Abstract excerpt
This study sought to address the relationship between crocidolite and p53 gene mutation. The mutations of p53 gene in 8 BALB/c 3T3 cell lines transformed by crocidolite were analysed. Altogether 11 exons of the gene from 8 cell lines were detected by PCR-SSCP. 7 alterations were found; 2 of them were located in exon 4-6, and 5 in 9-11. Most of the mutations (5/7) were of one more band than that of wild cell from...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.
