Back to search

Article

The <i>E. coli</i> pathobiont LF82 encodes a unique variant of σ <sup>70</sup> that results in specific gene expression changes and altered phenotypes

2023-02-08

Abstract excerpt

LF82, an adherent invasive Escherichia coli pathobiont, is associated with ileal Crohn’s disease, an inflammatory bowel disease of unknown etiology. Although LF82 contains no virulence genes, it carries several genetic differences, including single nucleotide polymorphisms (SNPs), that distinguish it from nonpathogenic E. coli . We have identified and investigated an extremely rare SNP that is within the highly...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
1a8d7bc0-500c-5f33-9abc-b9933298232a
DOI
10.1101/2023.02.08.523653
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
The <i>E. coli</i> pathobiont LF82 encodes a unique variant of σ <sup>70</sup> that results in specific gene expression changes and altered phenotypesDOI 10.1101/2023.02.08.523653
A single rare σ70 variant establishes a unique gene expression pattern in the E. coli pathobiont LF82.Semantic proximity
Escherichia coli pathobionts and Crohn's disease: varied genetic paths leading to similar phenotypes.Semantic proximity
Allele-Specific Effects of Mutations in the Rifampin Resistance-Determining Region (RRDR) of RpoB on Physiology and Antibiotic Resistance in <i>Enterococcus faecium</i>Semantic proximity
Long-read sequencing to interrogate strain-level variation among adherent-invasive <i>Escherichia coli</i> isolated from human intestinal tissueSemantic proximity
Genotypic and phenotypic characterization of <i>Enterococcus faecalis</i> isolates from periprosthetic joint infectionsSemantic proximity
<i>E. coli</i> associated with Crohn’s disease exhibit distinct strategies to colonize macrophagesSemantic proximity
Influence of the Alternative Sigma Factor RpoN on Global Gene Expression and Carbon Catabolism in Enterococcus faecalis V583Semantic proximity
The δ Subunit of RNA Polymerase Guides Promoter Selectivity and Virulence in Staphylococcus aureusSemantic proximity
The Alternative Sigma Factor SigL Influences <i>Clostridioides difficile</i> Toxin Production, Sporulation, and Cell Surface PropertiesSemantic proximity
Mutations in RNA polymerase that drive the emergence of antibiotic resistance.Semantic proximity
Heterogeneity among Clinical Intestinal Escherichia coli Isolates upon Acquired Streptomycin Resistance.Semantic proximity
The Small RNA MicC is a Multifunctional Regulator of Extraintestinal Pathogenic <i>Escherichia coli</i> Fitness across Multiple Host NichesSemantic proximity
Select a neighboring publication to make it the new centre.