Article
Neuroinflammation and the genetics of Alzheimer's disease: the search for a pro-inflammatory phenotype.
Aging (Milan, Italy) - 1 Jun 2001
Franceschi C, Valensin S, Lescai F, Olivieri F, Licastro F, Grimaldi L M, Monti D, De Benedictis G, Bonafè M
Abstract excerpt
The role of interleukin 1 (IL-1) and interleukin 6 (IL-6) in the pathogenesis of Alzheimer's disease (AD) is reviewed within the framework of "inflamm-aging", i.e., the characteristic chronic pro-inflammatory status which develops in old age, and neuroinflammation, i.e., the peculiar inflammatory process which is present in the brain of AD patients. In particular, the data suggesting that several IL-1 and IL-6...
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