Article
The Drosophila dCREB2 gene affects the circadian clock.
Neuron - 1 Apr 1999
Belvin M P, Zhou H, Yin J C
Abstract excerpt
We report the role of dCREB2, the Drosophila homolog of CREB/CREM, in circadian rhythms. dCREB2 activity cycles with a 24 hr rhythm in flies, both in a light:dark cycle and in constant darkness. A mutation in dCREB2 shortens circadian locomotor rhythm in flies and dampens the oscillation of period, a known clock gene. Cycling dCREB2 activity is abolished in a period mutant, indicating that dCREB2 and Period...
Topics
- Animals
- Circadian Rhythm
- Cyclic AMP Response Element-Binding Protein
- Drosophila
- Feedback
- Female
- Genes, Insect
- Luciferases
- Mutation
- Oscillometry
- Phenotype
- Recombinant Fusion Proteins