Article
The Drosophila dCREB2 gene affects the circadian clock.
Neuron - 1 Apr 1999
Belvin M P, Zhou H, Yin J C
Abstract excerpt
We report the role of dCREB2, the Drosophila homolog of CREB/CREM, in circadian rhythms. dCREB2 activity cycles with a 24 hr rhythm in flies, both in a light:dark cycle and in constant darkness. A mutation in dCREB2 shortens circadian locomotor rhythm in flies and dampens the oscillation of period, a known clock gene. Cycling dCREB2 activity is abolished in a period mutant, indicating that dCREB2 and Period...
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