Article
CREB as a memory modulator: induced expression of a dCREB2 activator isoform enhances long-term memory in Drosophila.
Cell - 7 Apr 1995
Yin J C, Del Vecchio M, Zhou H, Tully T
Abstract excerpt
Genetic studies of memory formation in Drosophila have revealed that the formation of a protein synthesis-dependent long-term memory (LTM) requires multiple training sessions. LTM is blocked specifically by induced expression of a repressor isoform of the cAMP-responsive element-binding protein (CREB). Here, we report an enhancement of LTM formation after induced expression of an activator isoform of dCREB2....
Topics
- Animals
- Animals, Genetically Modified
- Avoidance Learning
- Cyclic AMP Response Element-Binding Protein
- Drosophila
- Gene Expression
- Genes, Insect
- Hot Temperature
- Memory
- Models, Genetic
- Mutation