ARH cooperates with AP-1B in the exocytosis of LDLR in polarized epithelial cells.

doi:10.1083/jcb.201012121

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Article

ARH cooperates with AP-1B in the exocytosis of LDLR in polarized epithelial cells.

The Journal of cell biology - 4 Apr 2011

Kang Richard S, Fölsch Heike

Abstract excerpt

The autosomal recessive hypercholesterolemia protein (ARH) is well known for its role in clathrin-mediated endocytosis of low-density lipoprotein receptors (LDLRs). During uptake, ARH directly binds to the FxNPxY signal in the cytoplasmic tail of LDLR. Interestingly, the same FxNPxY motif is used in basolateral exocytosis of LDLR from recycling endosomes (REs), which is facilitated by the epithelial-specific...

Topics

3T3 Cells
Adaptor Protein Complex 1
Adaptor Proteins, Signal Transducing
Animals
Cells, Cultured
Endosomes
Epithelial Cells
Exocytosis
Humans
Mice
Models, Biological
Mutation
Receptors, LDL
Reverse Transcriptase Polymerase Chain Reaction

Source

Open in PubMed Open full text

Identifiers

PMID: 21444685
DOI: 10.1083/jcb.201012121
PMCID: PMC3082197

Genes

LDLR

Provenance

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