Article
Two independent targeting signals in the cytoplasmic domain determine trans-Golgi network localization and endosomal trafficking of the proprotein convertase furin.
The EMBO journal - 1 Jun 1995
Schäfer W, Stroh A, Berghöfer S, Seiler J, Vey M, Kruse M L, Kern H F, Klenk H D, Garten W
Abstract excerpt
Furin, a subtilisin-like eukaryotic endoprotease, is responsible for proteolytic cleavage of cellular and viral proteins transported via the constitutive secretory pathway. Cleavage occurs at the C-terminus of basic amino acid sequences, such as R-X-K/R-R and R-X-X-R. Furin was found predominantly in the trans-Golgi network (TGN), but also in clathrin-coated vesicles dispatched from the TGN, on the plasma...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.