Article
Secretion of a peripheral membrane protein, MFG-E8, as a complex with membrane vesicles.
European journal of biochemistry - 1 Feb 2002
Oshima Kenji, Aoki Naohito, Kato Takeo, Kitajima Ken, Matsuda Tsukasa
Abstract excerpt
MFG-E8 (milk fat globule-EGF factor 8) is a peripheral membrane glycoprotein, which is expressed abundantly in lactating mammary glands and is secreted in association with fat globules. This protein consists of two-repeated EGF-like domains, a mucin-like domain and two-repeated discoidin-like domains (C-domains), and contains an integrin-binding motif (RGD sequence) in the EGF-like domain. To clarify the role of...
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