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Article

BMP receptor IA is required in the mammalian embryo for endodermal morphogenesis and ectodermal patterning.

Developmental biology - 1 Jun 2004

Davis Shannon, Miura Shigeto, Hill Christin, Mishina Yuji, Klingensmith John

Abstract excerpt

BMPRIA is a receptor for bone morphogenetic proteins with high affinity for BMP2 and BMP4. Mouse embryos lacking Bmpr1a fail to gastrulate, complicating studies on the requirements for BMP signaling in germ layer development. Recent work shows that BMP4 produced in extraembryonic tissues initiates gastrulation. Here we use a conditional allele of Bmpr1a to remove BMPRIA only in the epiblast, which gives rise to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 15136140
DOI: 10.1016/j.ydbio.2004.01.048

Genes

BMP4
BMP2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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