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Article

Identification of virulence genes of Helicobacter pylori by random insertion mutagenesis.

Infection and immunity - 1 May 1999

Bijlsma J J, Vandenbroucke-Grauls C M, Phadnis S H, Kusters J G

Abstract excerpt

The complete genome of the gram-negative bacterial pathogen Helicobacter pylori, an important etiological agent of gastroduodenal disease in humans, has recently been published. This sequence revealed that the putative products of roughly one-third of the open reading frames (ORFs) have no significant homology to any known proteins. To be able to analyze the functions of all ORFs, we constructed an integration...

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Identifiers

PMID: 10225906
DOI: 10.1128/IAI.67.5.2433-2440.1999
PMCID: PMC115989

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