Article
Proteus mirabilis genes that contribute to pathogenesis of urinary tract infection: identification of 25 signature-tagged mutants attenuated at least 100-fold.
Infection and immunity - 1 May 2004
Burall Laurel S, Harro Janette M, Li Xin, Lockatell C Virginia, Himpsl Stephanie D, Hebel J Richard, Johnson David E, Mobley Harry L T
Abstract excerpt
Proteus mirabilis, a common cause of urinary tract infections (UTI) in individuals with functional or structural abnormalities or with long-term catheterization, forms bladder and kidney stones as a consequence of urease-mediated urea hydrolysis. Known virulence factors, besides urease, are hemolysin, fimbriae, metalloproteases, and flagella. In this study we utilized the CBA mouse model of ascending UTI to...
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