Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

SEC14-dependent secretion in Saccharomyces cerevisiae. Nondependence on sphingolipid synthesis-coupled diacylglycerol production.

The Journal of biological chemistry - 7 May 1999

Stock S D, Hama H, DeWald D B, Takemoto J Y

Abstract excerpt

The SEC14 gene in Saccharomyces cerevisiae encodes a phosphatidylinositol transfer protein required for secretory protein movement from the Golgi. Mutation of SAC1, a gene of unknown function, restores secretory flow in sec14-1(ts) strains. The existing model for the bypass of the sec14-1(ts) defect by sac1-22 involves stimulation of sphingolipid biosynthesis and, in particular, the synthesis of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Carrier Proteins
Share to Diglycerides
Share to Phosphatidylinositol Phosphates

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Phospholipid Transfer Proteins

Share to Phosphotransferases (Alcohol Group Acceptor)

Share to Saccharomyces cerevisiae

Share to Saccharomyces cerevisiae Proteins

Share to Sphingolipids

Source

Identifiers

PMID: 10224046
DOI: 10.1074/jbc.274.19.12979

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

SEC14-dependent secretion in Saccharomyces cerevisiae. Nondependence on sphingolipid synthesis-coupled diacylglycerol production.PMID 10224046Read ↗

Direct involvement of phosphatidylinositol 4-phosphate in secretion in the yeast Saccharomyces cerevisiae.Semantic proximity Read ↗

Pleiotropic alterations in lipid metabolism in yeast sac1 mutants: relationship to "bypass Sec14p" and inositol auxotrophy.Semantic proximity Read ↗

SAC1p is an integral membrane protein that influences the cellular requirement for phospholipid transfer protein function and inositol in yeast.Semantic proximity Read ↗

A role for phospholipase D (Pld1p) in growth, secretion, and regulation of membrane lipid synthesis in yeast.Semantic proximity Read ↗

A phosphatidylinositol transfer protein controls the phosphatidylcholine content of yeast Golgi membranes.Semantic proximity Read ↗

An essential role for a phospholipid transfer protein in yeast Golgi function.Semantic proximity Read ↗

The Saccharomyces cerevisiae phosphatidylinositol-transfer protein effects a ligand-dependent inhibition of choline-phosphate cytidylyltransferase activity.Semantic proximity Read ↗

Biosynthesis of mannosylinositolphosphoceramide in Saccharomyces cerevisiae is dependent on genes controlling the flow of secretory vesicles from the endoplasmic reticulum to the Golgi.Semantic proximity Read ↗

Regulation of intracellular phosphatidylinositol-4-phosphate by the Sac1 lipid phosphatase.Semantic proximity Read ↗

Protein sorting in the late Golgi of Saccharomyces cerevisiae does not require mannosylated sphingolipids.Semantic proximity Read ↗

SPO14 separation-of-function mutations define unique roles for phospholipase D in secretion and cellular differentiation in Saccharomyces cerevisiae.Semantic proximity Read ↗

Synthesis of mannose-(inositol-P)2-ceramide, the major sphingolipid in Saccharomyces cerevisiae, requires the IPT1 (YDR072c) gene.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.